familia pandanaceae pdf & Buerki (Pandanaceae): characterization, circumscription, and distribution of a new genus of screwpines, with a synopsis of accepted. Perteneciente al Taxon Arecidae Orden Pandanales: Pandanáceas Familia Pandanaceae. Done. Comment. 29 views. 0 faves. 0 comments. Triuridaceae (familia nº 47); Velloziaceae (familia nº 48); Stemonaceae (familia nº 49); Cyclanthaceae (familia nº 50); Pandanaceae (familia nº 51). sensu APG III .
|Published (Last):||26 June 2004|
|PDF File Size:||15.76 Mb|
|ePub File Size:||19.44 Mb|
|Price:||Free* [*Free Regsitration Required]|
In this study, several neuropharmacological effects of methanolic leaf extract of Pandanus odoratissimus PO family; Pandanaceae were studied in albino mice using various experimental models. The effect of PO on the CNS was studied by using different neuropharmacological paradigms pandanaceqe spontaneous motor activity, rota-rod performance and potentiation of Pentobarbital sodium sleeping time in albino mice. Preliminary qualitative chemical studies indicated the presence of steroids, saponins, terpinoids, glycosides, tannins, flavonoids and phenolics in the extract.
These observations suggest that the leaf of Pandanus odoratissimus contains some active principles which possess potential CNS-depressant action.
Potential of Pandanus odoratissimus as a CNS depressant in Swiss albino mice
Pandanus odoratissimus is said to be a restorative, indolent, promoting a feeling of well-being and acting as a counter to tropical climates. It may be chewed as a breath sweetener or used as a preservative in foods. It is also believed to have health-related familja, including antiviral, panndanaceae, antiplatelet, anti-inflammatory, antioxidant and anticancer action.
Ayurvedic science has found the medicinal action of essential oil yielded by the screw pine’s highly scented flowers to be useful in headaches, earaches and as a liniment for rheumatic pains. Pandamaceae distilled water from flowers is used for inducing perspiration. It is also prescribed as a stimulant and an antispasmodic agent.
The flowers are powdered and included in medicines, which are either sniffed like snuff famioia smoked for asthma and other bronchial infections Keerthikar, Basu, The leaves are thought to be useful in leprosy, smallpox, scabies and diseases of the heart and brain. Medicinal oil is also prepared from the roots of Pandanus odoratissimus The Wealth of India The methanolic extract of the leaf is said to have moderate antioxidant activity because of its high phenolic content.
Other constituents present fwmilia the methanolic leaf extract are steroids, saponins, terpinoids, glycosides, tannins and flavonoids Londonkar et al. To the best of our knowledge, no studies on the Pandanus odoratissimus in the central nervous system have been reported. Pilot studies have indicated that leaf extract of Pandanus odoratissimus has a role in the CNS.
Based on this evidence, we investigated the activity of pandanaceaf methanolic extract of Pandanus odoratissimus famillia motor coordination, spontaneous motor activity and pentobarbital induced sleeping time pandajaceae albino mice.
Preparation of plant extract. The leaves of the herb Pandanus odoratissimus were collected in September from villages surrounding Chidambaram, Tamilnadu, India. The fresh leaves of Pandanus odoratissimus were then washed with running water. The leaves were shade dried at room temperature and 1 kg of the dried leaf was ground into coarse powder.
The powder was passed through a no. The ground power was extracted using methanol in a soxhlet apparatus Harborne, The extract was then evaporated under reduced pressure to give a dark green viscous mass. The methanolic extract a dark green viscous mass was dried and stored in a desiccator prior to use and gave a mean yield of Young adult Swiss albino mice weighing g of either sex were obtained from the central animal house of Annamalai University, Chidambaram, Tamilnadu, India.
The animals were fed with standard animal feed Hindustan Lever Ltd. Bangalore, India and water; animals were acclimatized to the laboratory conditions for 5 days prior to experimentation. Some of the drugs and chemicals used for carrying out the studies included: Experimental animals ;and administration. For determination of the dose of LD 50seven-week-old male and female albino mice, weighing between g were used. Animals were deprived of food but given water hours prior to dosing on day 0.
Observation of toxicity signs. Body weight, signs of toxicity general behavior, respiratory pattern, cardiovascular signs, motor activities, reflexes, and change in skin and fur and mortality were observed after administration at the first, second, fourth and sixth hour on the first day, and once daily for the proceeding 14 days OECD guidelines, Spontaneous motor activity SMA. After 30 min of treatment, for monitoring of the SMA each mouse was placed in a Plexiglass cage and isolated in the recording room.
The experiments were repeated at an interval of 30 min for a total of min. The sensing platform reacts to the lateral component of the animals’ movements and recordings of displacement were taken over min periods. Results of the treated groups were compared with those of the control group for each time interval Amos et al. Motor coordination by rota-rod test. Dunham and Miya suggested that skeletal muscle relaxation induced by a test compound could be evaluated by testing the ability of mice or rats to remain on a rotating rod.
For this purpose Rota-rod Techno, India biological research apparatus was used for the test. The instrument a horizontal rotation device was set at a rate of 16 revolutions per minute. Mice were placed on the rod and those that were able to remain on the rod longer than 3 min were selected for the study.
Mice unable to remain on the rod for at least three min were considered as a positive test and the time of their fall was recorded. Sodium pentobarbital induced sleeping time. Mice of either sex were randomly allocated to the different control and test groups 6 animals per group. The effects were recorded as follows: The mean values of the results from the control group were compared to the mean values of groups treated with extract using the Dunnett post hoc test.
Acute toxicity and general behavioral studies. In both sexes of mice, body weight gain of treatment rats was not changed significantly relative to that of control.
Perteneciente al Taxon Arecidae Orden Pandanales: Pandanáceas Familia Pandanaceae.
While conducting the toxicity studies, animals were observed continuously for any general behavioral changes. A significant reduction in spontaneous locomotor motility, drowsiness and remarkably quiet behavior were observed. This effect was dose dependent and observed within 30 min of drug administration, persisting for min.
PO produced a marked reduction in motor coordination in mice where the animals were unable to remain on the rotating rod. This effect was dose-dependent and was observed within 30 min of drug administration, persisting for min. Various sleep times of mice treated with pentobarbital with or without extract are shown in Table III. In the present study, several neuropharmacological effects of PO in mice were reported, employing different validated animal models.
These actions were compared to the effects produced by Diazepam, a standard benzodiazepine commonly used as an anxiolytic in clinics. These results corroborate those of Fujimori et al. Our data showed that i. Spontaneous motor activity is a measure of the level of excitability of the CNS Mansur et al.
Agents that suppress this behavior usually do so through central inhibition Adzu et al. The test most widely employed to evaluate the putative hypnosedative properties of compounds with unknown central nervous system effects is barbiturate-induced sleep Duarte et al.
Pentobarbital sodium, when given at an appropriate dose, induces sedation or hypnosis in animals by potentiating GABA-mediated postsynaptic inhibition through allosteric modification of GABA receptors Collier et al. Substances that have CNS depressant activity either decrease the time for onset of sleep or prolong the duration of sleep or both. PO decreased the time for onset of sleep and also prolonged Pentobarbital sodium-induced sleeping time in a dose dependent fashion.
Prolongation of sodium pentobarbital-induced hypnosis is suggestive of central depressant activity of a compound Perez et al. The test for motor coordination rota rod performance was adopted to evaluate the effect of the extract on physical performance, endurance and possible neuromuscular inhibition.
The dopaminergic system has traditionally been regarded as crucial to the control of motor activity Petry et al. PO has a significant effect on in vivo muscle relaxant activity as indicated by positive results obtained in the grip strength test. Therefore, this suggests that the extract has centrally-mediated actions. Phytochemical analysis of the extract showed the presence of alkaloids, flavonoids, saponins, steroids, terpinoids, tannins and glycosides.
The saponins and flavonoids have been reported to be responsible for a sedative effect and likewise for inhibition of spontaneous motor activity in mice Musa et al.
These results are supported by several researchers Won et al. Reported pharmacological activities of PO could be attributed to the presence of saponins and flavonoids. Further studies focusing on the isolation and characterization of these secondary metabolites are needed. Based on the findings of the present study, it can be concluded that the methanolic leaf extract of Pandanus odoratissimus possesses significant CNS depressant activity. The depressant activity may be attributed to various mechanisms such as decreased serotonergic and dopaminergic transmission.
The present study is based upon the behavioral models with crude extract and without any associated neurochemical estimations.
Effect of Zizypus spinachristi wild aqueous extract on the central nervous system in mice. Behavioral effects of the aqueous extract of Guiera senegalensisi in mice and rats. The Wealth of India: The abdominal constriction response and its suppression by analgesic drugs in the mouse. Participation of dihydrostyrylpyrones and styrylpyrones in the central effects of Polygala sabulosa Polygalaceaea folk medicine topical anesthetic.
A note on a simple apparatus for detecting neurological deficit in rats and mice. Potentiation of barbital hypnosis as an evaluation method for central nervous system depressant. Chapman and Hall Publishers, Text book of Indian medicinal plants. International Book Distributors, Evaluation of free radical scavenging activity of Pandanus odoratissimus.
Effects of acute and chronic administration of cannabis satis and ” 9- trans tetrahydrocannabinol on the behaviour of rats in open field arena. Studies on the sedative effect of Cistanche deserticola.
Preliminary phytochemical screening and central nervous system depressant activity of the stem bark of Picus thoningii Blums. Guidelines for the Testing of Chemicals No. Effect of Hypericum Pericum L. Neuropharmacological activity of Solanum nigrum fruit.
Time sampling observation procedure for studying interaction between d-amphetamine and selective DA receptor in the rats.